ChloroquineV1, Main, Exploration, bibRecord, 003919

A defect in thromboxane a2 synthesis may be a factor predisposing to cancer

Identifieur interne : 003919 ( Main/Exploration ); précédent : 003918; suivant : 003920

A defect in thromboxane a2 synthesis may be a factor predisposing to cancer

Auteurs : D. F. Horrobin ; R. A. Karmali ; M. S. Manku ; A. I. Ally ; R. O. Morgan ; S. C. Cunnane ; M. Karmazyn

Source :

Prostaglandines and Medicine [ 0161-4630 ] ; 1978.

RBID : ISTEX:B21B8C8B38B614F7AF9176508504A114CE5FEE57

English descriptors

Teeft :
- Arch dermatol, Biochem biophys, Horrobin, Imidazole, Ionising radiation, Manku, Ornithine decarboxylase, Perspect biol, Primary event, Prostaglandin, Prostaglandin agonists, Psoriasis, Systemic lupus erythematosus, Thromboxane, Tumour, Txa2, Txa2 synthesis, Txae, Txae synthesis, Txaz synthesis, Xeroderma pigmentosum.

Abstract

Abstract: A failure of thromboxane (TX) A2 synthesis may be a factor in cancer. Such a loss could explain the susceptibility to mutation, the excess prostaglandin production, the glycolytic mode of metabolism and the deranged calcium pumping characteristic of cancers. Ionising radiation and phorbols both have actions similar to inhibitors of TXA2 synthesis whereas colchicine and oxygen have actions consistent with stimulation of TXA2 synthesis. The concept accounts logically for hitherto unexplained features of cancer and suggests new strategies for the prevention and treatment of cancer.

Url:

https://api.istex.fr/ark:/67375/6H6-FRZFT7W1-K/fulltext.pdf

DOI: 10.1016/0161-4630(78)90045-9

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000F05
to stream Istex, to step Curation: 000F05
to stream Istex, to step Checkpoint: 002671
to stream Main, to step Merge: 003998
to stream Main, to step Curation: 003919

Le document en format XML

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<term>Ionising radiation</term>
<term>Manku</term>
<term>Ornithine decarboxylase</term>
<term>Perspect biol</term>
<term>Primary event</term>
<term>Prostaglandin</term>
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<term>Txa2</term>
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<front><div type="abstract" xml:lang="en">Abstract: A failure of thromboxane (TX) A2 synthesis may be a factor in cancer. Such a loss could explain the susceptibility to mutation, the excess prostaglandin production, the glycolytic mode of metabolism and the deranged calcium pumping characteristic of cancers. Ionising radiation and phorbols both have actions similar to inhibitors of TXA2 synthesis whereas colchicine and oxygen have actions consistent with stimulation of TXA2 synthesis. The concept accounts logically for hitherto unexplained features of cancer and suggests new strategies for the prevention and treatment of cancer.</div>
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A defect in thromboxane a2 synthesis may be a factor predisposing to cancer

A defect in thromboxane a2 synthesis may be a factor predisposing to cancer

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri